| Fiction Best Sellers |
- Valley of the Dolls - Jacqueline Susann
- The Adventurers - Harold Robbins
- The Secret of Santa Vittoria - Robert Crichton
- Capable of Honor - Allen Drury
- The Double Image - Helen McInnes
- The Fixer - Bernard Malamud
- Tell No Man - Adela Rogers St. Johns
- Tai-Pan - James Clavell
- The Embezzler - Louis Auchincloss
- All in the Family - Edwin O'Connor
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| Nonfiction Best Sellers |
- How to Avoid Probate - Norman F. Dacey
- Human Sexual Response - William Masters, Virginia Johnson
- In Cold Blood - Truman Capote
- Games People Play - Eric Berne, M.D.
- A Thousand Days - Arthur M. Schlesinger, Jr.
- Everything But Money - Sam Levenson
- The Random House Dictionary of the English Language
- Rush to Judgement - Mark Lane
- The Last Battle - Cornelius Ryan
- Phyllis Diller's Housekeeping Hints - Phyllis Diller
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| Other Books released in 1966 |
- The Circle Game - Margaret Atwood
- The Dartmoor Worker anthology of William Crossing
- Der Meteor - Friedrich Dürrenmatt
- The Devil's Brigade - Robert H. Adleman
- Expeditions - Margaret Atwood
- Fantastic Voyage - Isaac Asimov
- Last Picture Show - Larry McMurtry
- The Master and Margarita - Mihail Bulgakov
- The Moon is a Harsh Mistress - Robert A. Heinlein
- The Soldier's Art - Anthony Powell
- The Solid Mandala - Patrick White
- Speeches for Doctor Frankenstein - Margaret Atwood
- The Sun King - Nancy Mitford
- Wide Sargasso Sea - Jean Rhys. This book is on the list of the 100 best English-language novels of the 20th century by the editorial board of the American Modern Library.
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| Hugo Awards (Science Fiction) |
- Frank Herbert - Author (Dune)
- Roger Zelazny, Author (... And Call Me Conrad)
- Frank Frazetta - Artist
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| Nebula Award (Science Fiction) |
- Samuel R. Delany - Babel-17
- Daniel Keyes - Flowers For Algernon
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| Nobel Prize for Literature |
- Shmuel Yosef Agnon
- Nelly Sachs
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| Pulitzer Prizes |
- Collected Stories of Katherine Anne Porter - Katherine Anne Porter (Fiction)
- Wandering Through Winter - Edwin Way Teale (Non-fiction)
- Selected Poems - Richard Eberhart (Poetry)
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